TB-500
Rebuilds injuries that won't heal.
TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (Tβ4), a naturally-occurring protein present in almost every human cell. When tissue is damaged, Tβ4 concentration rises at the injury site. TB-500 essentially replicates and amplifies that native repair signal, which is why it's frequently used for stubborn tendon, ligament, and joint injuries that plateau in normal rehab.
Binds and sequesters G-actin, promoting the actin polymerization needed for cell migration into wound sites. Upregulates VEGF-driven angiogenesis, downregulates inflammatory cytokines, and mobilizes progenitor stem cells to damaged tissue. The net effect is faster cell recruitment, better vascularization, and lower inflammatory burden during repair.
- E.01Preclinical evidence for accelerated dermal wound healing, cardiac tissue regeneration post-MI, and corneal repair.
- E.02Ongoing early-stage clinical trials for dry eye and epidermolysis bullosa (RGN-259, RGN-137).
- E.03Widely used off-label in veterinary sports medicine (racehorses).
Generally well-tolerated in reported use. Because it promotes cell proliferation and angiogenesis, avoid entirely if there is any history or active concern of cancer or abnormal cell growth. Not FDA-approved for human therapeutic use.
Frequently stacked with BPC-157 for compounded structural repair — the two work through different mechanisms and are considered complementary.
Research use only. Not FDA-approved.
How does TB-500 work?+
What are the reported benefits of TB-500?+
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This page summarizes publicly available research. Nothing here is medical advice, a prescription, or a diagnosis. Peptides described are not FDA-approved for the uses discussed unless explicitly noted. Consult a qualified physician before starting any protocol.