GHK-Cu
The aesthetic and longevity copper peptide.
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally-occurring tripeptide-copper complex present at high levels in young human plasma and steadily declining with age (from ~200 ng/mL at age 20 to ~80 ng/mL at 60). Decades of research — much of it by Dr. Loren Pickart — have established GHK-Cu as one of the most well-characterized regenerative peptides, especially for skin, hair, and wound repair.
Copper delivery to cells drives lysyl oxidase and superoxide dismutase activity. Directly upregulates collagen and elastin synthesis by fibroblasts, stimulates angiogenesis at wound sites, and modulates gene expression of over 4000 genes — many associated with tissue regeneration and DNA repair.
- E.01Peer-reviewed evidence for reduction in fine lines, improved skin thickness, and elasticity — both topical and injected forms.
- E.02Documented acceleration of wound healing in diabetic and non-diabetic models.
- E.03Hair follicle stimulation shown in cell-culture and animal studies; used topically for hair thinning.
- E.04Gene-expression studies suggest broad regenerative and anti-aging effects.
Excellent safety profile — used in cosmetics for decades. Topical application is essentially side-effect-free. Injected forms should be handled by knowledgeable practitioners.
Common with BPC-157 for structural and skin repair, and with retinoids topically for skin.
Widely used in cosmetics topically. Injected forms are research-use.
How does GHK-Cu work?+
What are the reported benefits of GHK-Cu?+
Is GHK-Cu safe?+
What is the regulatory status of GHK-Cu?+
This page summarizes publicly available research. Nothing here is medical advice, a prescription, or a diagnosis. Peptides described are not FDA-approved for the uses discussed unless explicitly noted. Consult a qualified physician before starting any protocol.